Join us to learn about polymer characterization via separation science, including applications, help selecting the right column, and speakers from the industry. Attendees will receive a complimentary gift.

Tuesday, August 12
12:30 pm - 3:00 pm
Moscone Center
Exhibit Halls B-C
Exhibitor Workshop Room 2

Seating for the workshop is limited, so please register in advance to reserve your seat!

You will receive a confirmatory email once your reservation is received.
12:30 pm – 1:15 pm
Guest Speaker and Topic: To be determined
1:15 pm – 1:45 pm
The Multiple Utilities of Gel Permeation Chromatography for Polymer Analysis
Amandaa Brewer, Ph.D., GPC Sales Support Leader, Tosoh Bioscience

Since its inception the principle use of gel permeation chromatography (GPC) has been to determine the molar mass averages and distributions of natural and synthetic polymers. In general these properties have been characterized through the application of calibration curves via a single-detector instrumental set-ups e.g. GPC-refractive index (RI). Over the years the complexity of polymers has increased, making the ability to obtain accurate and precise distributions of both their physical and chemical properties more difficult. These challenges have piloted a new era of polymer analysis: multi-detector GPC.

Here, we will discuss the multiple uses of single- and multi-detector GPC in the polymer industry, namely the coupling of GPC to various combinations of RI, UV-Vis, multi-angle light scattering (MALS), and differential viscometry (VISC) to detect differences from batch-to-batch or lot-to-lot of a given polymer, to monitor reaction processes, to determine variations in molar mass averages obtained through different synthesis routes, and to distinguish between polymers with the same chemical composition but different end-use properties. Additionally, we will provide an overview of using the addition of a MALS detector to a single-detector GPC system in a research and development type environment for the determination of not only the absolute, calibrant-independent, molar mass and molar mass distributions but also polymeric size information.
1:45 pm – 2:30 pm
Guest Speaker and Topic: To be determined
2:30 pm – 3:00 pm
High Temperature Gel Permeation Chromatography using Refractive Index Detection
Vaughn Williams, Laboratory Products Sales Specialist, Tosoh Bioscience LLC

The main utility of single-detector high temperature gel permeation chromatography (GPC) is to extract quantitative information from the elution curves obtained via a concentration sensitive detector with accuracy and precision. Traditionally, molar mass averages and distributions of polymers are determined using peak position calibration involving polystyrene standards of known molar mass and chemistry analyzed by GPC coupled to a differential refractive index detector (RI). The repeatability and reproducibility of the molar mass averages obtained by GPC/RI are directly dependent on the baseline stability of the RI detector.


Here, we introduce the newest GPC instrument from Tosoh Bioscience for polymer characterization, the EcoSEC High Temperature GPC System. The repeatability, reproducibility, and baseline stability of a dual flow RI detector in the EcoSEC High Temperature GPC System for the determination of molar mass averages via peak position calibration at temperatures up to 220 ° will be discussed. The dual flow RI detector design is shown to compensate for any changes in the refractive index of the solvent over time by continuously flowing pure solvent through the reference side of the flow cell, thus significantly increasing baseline stability of the RI detector and the repeatability and reproducibility of the molar mass averages. Additionally, the durability and stability of Tosoh Bioscience’s new high temperature GPC columns will be showcased.

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