Four is More! Selecting and Optimizing Quadruplet Therapy in NDMMHow I Practice Video ~ Efficacy of Quad Therapies*Pre-assessment* Survey

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2.What is your community of practice?

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3.In the IMROZ phase III trial of transplant-ineligible, newly diagnosed multiple myeloma (TIE NDMM), the addition of isatuximab to VRd (Isa VRd), followed by maintenance with Rd ± Isa, resulted in which of the following demonstrated outcomes?(Required.)

Significantly increased rates of MRD negativity that were not sustained beyond 12 months

Higher discontinuation rates secondary to increased toxicity

A statistically significant improvement in progression-free survival (PFS)

A statistically significant improvement in overall survival (OS)

4.Which one of the following patients is the most suitable candidate for initiating a quadruplet induction regimen in newly diagnosed multiple myeloma (NDMM)?(Required.)

A 65 year old woman with ECOG PS 3, significant cardiac and renal impairment, limited social support, and transplant-ineligible (TIE)

A 75 year old man with ECOG PS 0, minimal comorbidities, eligible for autologous SCT and strong social support

An 80 year old woman with ECOG PS 1, diabetes and peripheral neuropathy, and borderline transplant eligibility (TE)

A 72 year old man with ECOG PS 2, hypertension and early CKD, marginal social support, and transplant-ineligible (TIE)

5.Several phase III trials, including CEPHEUS and GMMG-HD7, have evaluated the impact of adding anti-CD38 antibodies to standard induction regimens in NDMM. Which of the following best describes the observed improvement in MRD-negativity rates following quadruplet induction therapy?

MRD-negativity rates are improved in both transplant-eligible (TE) and transplant-ineligible (TIE) patients, and progression-free survival (PFS) is prolonged

MRD-negativity rates are improved in both TE and TIE patients, but are not sustained over time

MRD-negativity rates are improved in both TE and TIE patients, but PFS is unaffected

MRD-negativity rates improve only in TE patients; no benefit is not observed in TIE patients

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