The FP7 project MITIGATE will develop a closed-loop molecular environment for minimally invasive treatment of patients with metastatic Gastrointestinal Stromal Tumours (GIST).

The MITIGATE consortium representing three European universities, three research organisations and four SMEs will pursue the ultimate goal to develop new protocols and guidelines to effectively diagnose and treat patients with metastatic GIST resistant to current treatment.
Standard endoscopic biopsy procedures require high human effort and skill. Furthermore, a consistent quality of biopsies is often not achieved due to different methods between surgeons.

To ensure a more standardised procedure, the MITIGATE project developed a novel endoscopic biopsy system. It enables physicians to sample tissue from submucosal tumours using a flexible endoscope. The biopsy device can be directly combined with a tissue dissociation module to allow specific cell isolation and subsequent analysis of the biopsy.
GOAL OF THIS SURVEY

The goal of this short survey (5 minutes) is to assess the end-user community and their interest in the products developed by MITIGATE.

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* 1. Where are you working?

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* 2. How many endoscopic biopsies does your institution perform per week?

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* 3. On average, how many biopsies does your institution perform per patient?

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* 4. How many of these biopsies are submucosal or would ideally reach beyond the mucosa layer?

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* 5. What type of endoscope(s) does your institution currently use?

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* 6. What biopsy instrument(s) does your institution currently use?

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* 7. What is the process for handling tissue samples at your institution?

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* 8. What process is your institution currently using to isolate tumour cells?

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* 9. How is the biopsy analysed?

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* 10. Would you be interested in a solution that integrates biopsy and tissue dissociation?

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* 11. What would you pay for such a solution?

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* 12. Which is the most common tissue source of GIST biopsy material that your institution extracts from patients?

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* 13. Are you working with any other tumour tissue in addition to GIST at your institution?

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* 14. If you are interested in learning more about the MITIGATE project and would like to receive our annual newsletter, please enter your contact details below.

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* 15. Do you have any general comments or remarks?

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