Apply approaches for detection of rare cells involved in human immune disease pathogenesis
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Restate that with improvements in peptide-MHC tetramer technology, we can now directly characterize specific T cells prior to any infection or stimulation in the pre-immune repertoire
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Contrast that in adults, but not newborns, there is an abundance of memory phenotype T cells in unexposed individuals, which may explain the susceptiblity of young children to infectious diseases
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Report how the Immune Epitope Database and Analysis Resource (IEDB), originally developed to focus on infectious disease data, can be used to analyze epitope data related to autoimmunity
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Examine how common questions related to diabetes epitopes can be answered using the IEDB and the results of the queries.
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