Proteomics technologies are an integral part of biological and clinical research. The ABRF Proteomics Standards Research Group (sPRG) functions to design and develop performance standards and resources for mass spectrometry-based proteomics applications. The sPRG is developing a new proteomic standard, derived from a series of stable isotope-labeled (“heavy”) peptides as internal standards conserved across Homo sapiens, Mus musculus and Rattus norvegicus. We invite you to participate in a collaborative study that focuses on the ability of core facilities to determine relative quantitation of up to 1,000 heavy/light peptide pairs in a single sample. Further information about the study can be found in the announcement letter and the participation letter provided with the samples on either the ABRF sPRG 2013 research study website or the ABRF sPRG Panorama website. Both websites contain the study announcement, study sample instructions, data reporting templates, FASTA databases, spectral libraries, skyline tutorial, and tutorial datasets.