WM Basics Quiz Survey

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* 1. WM is best classified as which type of cancer?

Hodgkin T-cell aggressive lymphoma

Acute leukemia

Non-Hodgkin B-cell indolent lymphoma

Plasma cell myeloma only

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* 2. To diagnose Waldenstrom macroglobulinemia (WM), which two components are required?

IgG monoclonal protein and plasma cell myeloma

IgM monoclonal protein and lymphoplasmacytic lymphoma (LPL) infiltrating the bone marrow

IgA monoclonal protein and Hodgkin lymphoma

High platelet count and enlarged spleen

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* 3. Which mutation is the most common driver of WM?

BCR-ABL

TP53 only

BRCA1

MYD88

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* 4. What is a common reason patients with WM first need treatment?

Hair loss

Anemia from bone marrow involvement

Skin rash only

Mild seasonal allergies

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* 5. What does hyperviscosity in WM result from?

Increased red blood cell production

Too little IgM in the blood

Low platelet counts only

Thickening of the blood due to high IgM levels

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* 6. Which symptom can be associated with hyperviscosity syndrome?

Blurry vision

Broken bones

Rash from sunlight

Frequent sneezing

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* 7. What is often the right initial approach for an asymptomatic patient with WM?

Immediate chemotherapy for everyone

Emergency surgery

Watchful waiting with monitoring

Radiation to the bone marrow

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* 8. What is the purpose of plasma exchange in WM?

To cure the lymphoma

To remove excess IgM quickly and reduce hyperviscosity symptoms

To increase bone marrow production permanently

To replace all white blood cells

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* 9. Which blood test finding may first alert a clinician to possible WM?

Elevated total protein or an IgM M-spike

Low sodium only

Low cholesterol

High calcium only

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* 10. Which of the following is considered a rare or less common complication of WM?

Seasonal flu

Appendicitis

Cold agglutinin disease

Asthma

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* 11. What is Bing-Neel syndrome?

A skin condition caused by chemotherapy

WM involvement of the central nervous system

A type of kidney stone

A vitamin deficiency

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* 12. What does transformation mean in WM?

The disease disappears on its own

IgM becomes IgA permanently

WM changes into a more aggressive lymphoma

Platelets return to normal

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* 13. Which statement best describes treatment options for WM?

Everyone with WM is treated the same way regardless of symptoms

Treatment depends on symptoms, complications, and disease features, and may include BTK inhibitors, rituximab, or chemoimmunotherapy

Surgery is the standard first treatment for most patients

Antibiotics are the primary treatment for WM