2023 Cancer Immunity & Immunotherapy Course Post-Test

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* 1. The subsets of cells in the TME and their different functional states are still being understood.

True

False

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* 2. The cellular hallmarks of tertiary lymphoid structure are:

B cells and CD4+ T Cells

PNAd (high endothelial venues)

follicular dendritic cells

CD8+ T cells

A, B, and C

A and B

All of the above

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* 3. Exhausted T cells:

Have impaired or absent cytoxic function and ability to produce effector cytokines

Express multiple inhibitory receptors including PD1, CTLA4, and LAG3

Have a unique transcription factor and epigenetic profile from functional effector and memory T cells

All of the above

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* 4. Antigen escape is a CAR-T resistance mechanism that has been most frequently described in clinical trials.

True

False

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* 5. Which of the following is considered as a potential risk factor contributing to immune-related adverse events biology?

Increasing T-cell activity against antigen that are present in tumors and healthy tissue

Increasing levels of pre-existing circulating autoantibodies ; C) Increasing levels of circulating inflammatory cytokine

Enhancing complement-mediated inflammation due to direct binding of an anti-CTLA4 antibody with CTLA-4 expressed on normal tissue

Genetically predisposed individuals

All of the above

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* 6. Cancer vaccines perform many functions, including:

Increasing the number of tumor infiltrating T cells

Expanding the T cell repertoire

Focusing the antitumor immune response

All of the above

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* 7. Which of the following immunotherapies is associated with the highest risk of life-threatening cytokine release syndrome (CRS)?

CAR NK cells

CAR Macrophages

CAR T cells

NK cell engagers

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* 8. cIAP inhibitors / SMAC mimetics have only an additive effect in combination with adoptive cell therapy because cIAP inhibitors sensitize tumor cells to apoptosis without any enhancement of antitumor immunity

True

False

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* 9. Which of the following/s best explains the use of systems approach for identifying adaptive resistance mechanisms to immunotherapies?

CRISPR-Cas9 mediated gene perturbation screens leverage discovery and validation of sensitizers of adoptive cell therapies against cancer

Two cell-type assay systems provide deep insights into the molecular mechanisms of resistance of cancer cells against T cell mediated killing

Oncogenic mutations that drive resistance to immunotherapies can be exploited for developing next generation of combination therapies

Human cancer genetic analytics from The Cancer Genome Atlas allows us to generate new hypotheses related to cancer immune escape

All of the above