Clevidipine Perioperative Use Questionnaire

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Clevidipine, brand name Cleviprex, is emulsified dihydropyridine calcium channel blocker (CCB), concentration of 0.5mg/ml with a rapid onset (2min), short duration (5-15min), and organ independent esterase metabolism. It targets the arteries reducing systemic vascular resistance while preserving preload, and increasing cardiac output. Heart rate is preserved and may increase in a dose dependent manner as blood pressure is reduced. Clevidipine is administered as a continuous infusion starting at 1mg/hr titrating up by doubling the dose every 90 seconds to a maximum rate of 32mg/hr, however due to lipid load of 0.2g/ml, 24-hour average rate should not exceed 21mg/hr. The most common maintenance dose is 4-6mg/hr. Clevidipine has also been used in bolus doses of 0.125-0.5mg prior to induction and prior to bypass cannulation during cardiac surgery, and up to 1mg bolus doses to treat hypertension in pheochromocytoma patients to correct hypertension within 90 seconds. (References available upon request)