June 2018 ASBMT Monthly Self-Directed Learning Quiz

On behalf of the ASBMT Committee on Education, we are pleased to continue our monthly self-directed learning quiz "Basic Principles and Practices of Hematopoietic Cell Transplantation and Cell Therapy – Question and Answer Approach” for fellows in training, highlighting HCT and cell therapy topics. Answers to each question appear with evidence-based “non-exhaustive” peer-review commentary. Our aim is to provide you with a credible and freely available educational resource. Questions generated and reviewed by Syed Abutalib, MD, Mark R. Litzow, MD, and William A. Wood, MD.

Question Title

* 1. Which statement about parainfluenza virus infection after hematopoietic cell transplant is NOT correct?

A. In several prospective studies, ribavirin had no impact on progression from upper to lower respiratory tract infection

B. Data do not support treating patients with parainfluenza virus associated upper respiratory tract infection.

C. The treatment with intravenous immunoglobulins remains controversial.

D. The treatment with ribavirin remains controversial.

Question Title

* 2. Which statement about trends of autologous hematopoietic cell transplants in U.S is correct?

A. In 2016, the number of transplants for lymphomas increased

B. In 2016, the number of transplants for multiple myeloma decreased

C. In 2016, the number of transplants for lymphomas decreased

D. Choices A and B are correct

Question Title

* 3. Which allogeneic recipient with HLA-mismatch transplant is more likely to develop anti-HLA antibody or antibodies?

A. Child to mother HLA-mismatch haploidentical transplant

B. History of allogeneic blood transfusion(s)

C. Multiparous recipient

D. All of the above

Question Title

* 4. Which statement about anti-HLA antibody or antibodies is NOT correct?

A. Not all anti-HLA antibodies are directed against donor’s mismatch HLA antigens

B. Evaluation of anti-HLA antibodies should be performed in all patients receiving HLA-mismatch transplants

C. The risk of transfusion-associated HLA alloimmunization is higher in patients receiving red blood cell transfusion compared to platelet transfusion

D. Anti-HLA antibodies may be unique to a specific allele or limited group, or recognize an epitope that is shared by more than one HLA molecules

Question Title

* 5. Which statement about genome editing approaches is correct?

A. They can mediate gene addition only

B. They rely on bacterial nucleases only

C. They can be performed only on cells ex vivo

D. Advancement in genome editing with programmable nucleases have revolutionized gene therapy