The NIH is interested in mechanisms related to the processes and outcomes associated with both aggression perpetration and the impact of aggression on victims. This RFI is specifically requesting information to gain feedback, comments, and novel ideas from members of the scientific community to help identify the gaps and opportunities for research on the biobehavioral mechanisms of aggression and its interactions with other health risks.

NIH invites input from the scientific community, including but not limited to researchers and trainees across academia, industry, and government; health care providers, healthcare professional organizations and patient advocacy organizations; small businesses and the pharmaceutical/biotechnology industry; nongovernmental, scientific and professional organizations; and Federal agencies. Additional stakeholders representing other segments of the American public are also invited to submit comments related to this research. Organizations are strongly encouraged to submit a single response that reflects the views of their organization and membership as a whole.

How to Submit a Response

Responses must be received by 11:59pm ET on January 31, 2022, to be considered. You will see an electronic confirmation acknowledging receipt of your response.

Responses are voluntary and may be submitted anonymously. Please do not include any personally identifiable or other information that you do not wish to make public. No proprietary, classified, confidential, or sensitive information should be included in your response. NIH will use all information submitted in response to this RFI Notice at its discretion and will not provide comments to any responder’s submission. NIH may use information gathered by this RFI Notice to inform the development of future funding opportunity announcements and/or in any resultant solicitations.

This RFI Notice is for information and planning purpose only and should not be interpreted as a solicitation or as an obligation on the part of the Federal Government and/or the NIH. No monetary awards will be made to pay for the preparation of any information submitted or for the Government’s use of such information. No basis for claims against the U.S. Government shall arise as a result of a response to this request for information or from the Government’s use of such information.

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* 1. Name:

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* 2. Email:

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* 4. Organization Name:

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* 5. Role:

Information Requested

We are requesting information on the challenges and research gaps and opportunities that can best be addressed through a concerted and coordinated effort to enhance research on the biobehavioral contributions to aggressive behavior and its impact across the lifespan. Specifically, respondents are asked to provide input on any of the following:

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* 6. Gaps and opportunities in our fundamental understanding of biobehavioral mechanisms of aggression in humans and animals:

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* 7. Gaps and opportunities in the development and use of methods, tools, technology, or other research resources to enable better characterization of the biological, psychological, and environmental mechanisms underlying aggressive behaviors and the biobehavioral impact of those experiencing aggression:

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* 8. Gaps and opportunities in the identification of biomedical, behavioral, and psychosocial intervention targets for preventing and treating aggressive behavior and mitigating its impact on health and well being:

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* 9. Gaps and opportunities in the characterization of multimodal / multivariate approaches applicable to either primary or secondary data to understanding how other biological, behavioral and/or social/environmental factors such as alcohol and substance use or gender norms interact to influence aggression:

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* 10. Gaps and opportunities in the considerations of ethical, legal, and social implications for research investigating the biobehavioral mechanisms of aggression, including implications for applied work in human research:

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* 11. Any other issues that NIH should consider that may advance research on identifying neurobiological mechanistic approaches and potential intervention targets for preventing/treating aggressive behavior and/or mitigating its impacts across the lifespan:

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