1.
Current usage:
What are the current diagnostic methods you use to assess response to solid tumor therapy when using ImmunoOncology (IO)?
Please check all that apply
CT
MRI
PET
SPECT
Liquid biopsy Guardan
Liquid Biopsy other
Other (please specify)
2.
Time to test:
At what time point(s) do you routinely do imaging or other tests to assess response?
Week 1-3
Week 4-5
Week 5-8
3 months
6 months or more
I only order imaging if there are clinical signs of progression
It varies by cancer, I strictly follow NCCN guidelines
Other (please specify)
3.
Utility of test:
If the patient is on IO and the initial scan shows some enlargement, what is your usual/preferred response?
Please check all that apply
Change to another type of therapy
Immediately order another type of scan for verification
Wait one month and rescan
Wait 3 months and rescan
Order a liquid biopsy test
Other (please specify)
4.
Test result reporting:
For currently available liquid biopsy tests - what is the typical lag time - including preapproval, scheduling, performing, reading and reporting – between when you order a liquid biopsy, for any purpose, and when you receive the final report?
Less than 3 days
3-7 days
7-14 days
14-21 days
21 days or more
5.
For the all questions below assume there was a test that was both inexpensive and reliable, that could determine biochemically, using cfDNA methylation, if a therapy for advanced cancer was working early in the course of treatment. Assume a University of Colorado lab supplied the result the day of receipt.
Please check all that apply.
Therapy Evaluation:
Would you use this test?
Yes -routinely to reassure patients that the therapy is working
Yes -routinely to see if therapy needs to be changed
Yes - for patients on chemotherapy
Yes – for patients on immunotherapy
Yes – for therapies that may cause hyper-progression
Yes – to check for pseudo-progression
No – for all
6.
Your location vs. Mail in Lab Testing: :
If you could do this test in your office lab instead of waiting for overnight lab results, would you use it more?
A lot more
A little more
I don’t have a closely associated lab
I'd still prefer sending it to a lab
7.
Importance of Therapy Outcome Information:
How important is it for you and your patients’/families to know if a new treatment is reducing or controlling cancer?
Please check all that apply
Extremely important
Somewhat important
It would change my treatment plan
It wouldn't change my treatment plan
Not at all important
It adds risk
It adds burden
8.
Testing Frequency with Plasma vs. Urine Samples:
How often would you use the test described above, and would the sample type (plasma or urine) matter?
Please check all that apply
Weekly
– Plasma
Weekly
– Urine
Monthly
– Plasma
Monthly
– Urine
Quarterly
– Plasma
Quarterly
– Urine
q 6 months
– Plasma
q 6 months
– Urine
I would use it if/when requested by the patient
I would not be using it to monitor therapy in advanced cancer.
9.
What price
would make such a test
too expensive
to use monthly whether, reimbursed (by CMS and others) or self-pay ?
Please check one for reimbursed and one for self-pay.
$100
- reimbursed
$100
- self-pay
$200
- reimbursed
$200
- self-pay
$500
- reimbursed
$500
- self-pay
$750
- reimbursed
$750
- self-pay
$1000
- reimbursed
$1000
- self-pay
Other (please specify)
10.
Hospice Care : Therapy to reduce the growth rate of cancer in a hospice setting may reduce symptoms, however it may also cause side effects : in what percent of patients would you test to see if a therapy was having an effect on cancer growth?
10% or less
10 - 30%
30 - 50%
50 - 70%
70% or more
I don’t continue any anticancer treatment in hospice.
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