Question Title 1. Current usage: What are the current diagnostic methods you use to assess response to solid tumor therapy when using ImmunoOncology (IO)? Please check all that apply CT MRI PET SPECT Liquid biopsy Guardan Liquid Biopsy other Other (please specify) Question Title 2. Time to test: At what time point(s) do you routinely do imaging or other tests to assess response? Week 1-3 Week 4-5 Week 5-8 3 months 6 months or more I only order imaging if there are clinical signs of progression It varies by cancer, I strictly follow NCCN guidelines Other (please specify) Question Title 3. Utility of test: If the patient is on IO and the initial scan shows some enlargement, what is your usual/preferred response? Please check all that apply Change to another type of therapy Immediately order another type of scan for verification Wait one month and rescan Wait 3 months and rescan Order a liquid biopsy test Other (please specify) Question Title 4. Test result reporting: For currently available liquid biopsy tests - what is the typical lag time - including preapproval, scheduling, performing, reading and reporting – between when you order a liquid biopsy, for any purpose, and when you receive the final report? Less than 3 days 3-7 days 7-14 days 14-21 days 21 days or more Question Title 5. For the all questions below assume there was a test that was both inexpensive and reliable, that could determine biochemically, using cfDNA methylation, if a therapy for advanced cancer was working early in the course of treatment. Assume a University of Colorado lab supplied the result the day of receipt. Please check all that apply. Therapy Evaluation: Would you use this test? Yes -routinely to reassure patients that the therapy is working Yes -routinely to see if therapy needs to be changed Yes - for patients on chemotherapy Yes – for patients on immunotherapy Yes – for therapies that may cause hyper-progression Yes – to check for pseudo-progression No – for all Question Title 6. Your location vs. Mail in Lab Testing: : If you could do this test in your office lab instead of waiting for overnight lab results, would you use it more? A lot more A little more I don’t have a closely associated lab I'd still prefer sending it to a lab Question Title 7. Importance of Therapy Outcome Information: How important is it for you and your patients’/families to know if a new treatment is reducing or controlling cancer? Please check all that apply Extremely important Somewhat important It would change my treatment plan It wouldn't change my treatment plan Not at all important It adds risk It adds burden Question Title 8. Testing Frequency with Plasma vs. Urine Samples:How often would you use the test described above, and would the sample type (plasma or urine) matter? Please check all that apply Weekly – Plasma Weekly – Urine Monthly – Plasma Monthly – Urine Quarterly – Plasma Quarterly – Urine q 6 months – Plasma q 6 months – Urine I would use it if/when requested by the patient I would not be using it to monitor therapy in advanced cancer. Question Title 9. What price would make such a test too expensive to use monthly whether, reimbursed (by CMS and others) or self-pay ?Please check one for reimbursed and one for self-pay. $100 - reimbursed $100 - self-pay $200 - reimbursed $200 - self-pay $500 - reimbursed $500 - self-pay $750 - reimbursed $750 - self-pay $1000 - reimbursed $1000 - self-pay Other (please specify) Question Title 10. Hospice Care : Therapy to reduce the growth rate of cancer in a hospice setting may reduce symptoms, however it may also cause side effects : in what percent of patients would you test to see if a therapy was having an effect on cancer growth? 10% or less 10 - 30% 30 - 50% 50 - 70% 70% or more I don’t continue any anticancer treatment in hospice. Please add your email so we can arrange to send you payment!! Thanks! Done