NBCC LEADcast Quiz - Dr. Dennis Slamon

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* 1. Which cancers did not see much benefit from the “one size fits all” combination chemotherapy approach to cancer?

Colorectal

Lung

Prostate

All of the above

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* 2. What does Dr. Slamon consider one of the most important steps forward in the treatment of cancer?

The formation of TRIO

The acceptance that cancer is not a monolithic disease

The codification of the FDA’s approval process

All the above

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* 3. What type of traditional treatment is used for tumors that are considered high risk?

Surgery

Radiation therapy

Systemic chemotherapy or hormonal therapy

None of the above

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* 4. True or False: All cancer is genetic, but not all cancer is inherited.

True

False

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* 5. Some of the key hallmarks of cancer include:

Avoiding immune destruction

Sustained proliferation

Enabling replicative immortality

All of the above

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* 6. Which is the best description of the role of a CDK enzyme?

Regulating the process of transcription and proliferation during the cell cycle

Targeting foreign infections in the body

Allowing cancer cells to travel to other parts of the body

None of the above

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* 7. True or False: Dr. Slamon’s lab found that palbociclib (a CDK-4/6 inhibitor) was most effective in triple-negative breast cancer.

True

False

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* 8. What is the most common subtype of breast cancer?

Triple-negative

Hormone Receptor-Positive

HER2 Positive

None of the above

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* 9. What was the average difference in progression-free survival Dr. Slamon and his team found during the Phase II trial of patients receiving a CDK-4/6 inhibitor versus those receiving only standard of care?

10 months

24 months

6 months

18 months

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* 10. Major side effects of palbociclib differ from chemotherapy in which crucial way?

Does not cause nausea or vomiting

Arrests white blood cells rather than killing them

Causes potential fertility problems

None of the above