On behalf of the ASTCT Committee on Education, we are pleased to continue our monthly self-directed learning quiz "Basic Principles and Practices of Hematopoietic Cell Transplantation and Cell Therapy – Question and Answer Approach” for fellows in training, highlighting HCT and cell therapy topics. Answers to each question appear with evidence-based “non-exhaustive” peer-review commentary. Our aim is to provide you with a credible and freely available educational resource. Questions generated and reviewed by Syed Abutalib, MD, Amrita Krishnan, MD, and William A. Wood, MD.

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* 1. Which of the following defines bronchiolitis obliterans syndrome after hematopoietic cell transplantation?

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* 2. What is the recommended time for initial screening pulmonary function test (PFT) after allogeneic hematopoietic cell transplantation?

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* 3. Which of the following statements about cryptogenic-organizing pneumonia (COP) after hematopoietic cell transplantation is CORRECT?

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* 4. All of the following are important considerations in the management of bronchiolitis obliterans syndrome EXCEPT?

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* 5. FAM (inhaled Fluticasone, Azithromycin, and Montelukast) therapy with steroid pulse is frequently utilized in the management of new-onset bronchiolitis obliterans syndrome (BOS).  What are the proposed mechanism of actions of azithromycin and montelukast in BOS?

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