1A-1: demonstrates substantial local invasion precluding complete surgical resection.
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1A-2: involves an anatomic location in which surgery and/or radiation would result in severe disfigurement or dysfunction.
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1A-3: is recurrent following 2 or more prior surgical resections by a surgeon experienced in treating cutaneous cancer and for which further curative resection is deemed unlikely to clear margins and obtain long term cure/disease control.
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1A-4: is judged unlikely to respond to radiotherapy by a radiation oncologist experienced in treating cutaneous cancers.
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1A-5: arises in a previously irradiated site where re-irradiation would exceed cumulative dose threshold as determined by a radiation oncologist experienced in treating cutaneous cancers.
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1A-6: includes in transit metastasis between the primary cSCC and anticipated surrounding draining lymph nodes.
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