July 2018 ASBMT Monthly Self-Directed Learning Quiz

On behalf of the ASBMT Committee on Education, we are pleased to continue our monthly self-directed learning quiz "Basic Principles and Practices of Hematopoietic Cell Transplantation and Cell Therapy – Question and Answer Approach” for fellows in training, highlighting HCT and cell therapy topics. Answers to each question appear with evidence-based “non-exhaustive” peer-review commentary. Our aim is to provide you with a credible and freely available educational resource. Questions generated and reviewed by Syed Abutalib, MD, Mark R. Litzow, MD, and William A. Wood, MD.

Question Title

* 1. Which statement about engraftment syndrome is INCORRECT?

Spitzer criteria may be used to diagnose this clinical condition

It does not occur in the setting of allogeneic hematopoietic cell transplant

Maiolino criteria may be used to diagnose this clinical

G-CSF should be stopped immediately

Question Title

* 2. According to data reported to CIBMTR, what is the approximate 3-year overall survival among auto-transplant recipients for multiple myeloma in the years since 2005?

50-60%

60-70%

70-80%

80-90%

Question Title

* 3. Which statement about chimeric antigen receptor modified T cell (CAR T cell) therapy is INCORRECT?

CAR T cell therapy has the ability to harness a patient's immune system to target neoplastic cells

Mechanisms of reducing toxicities and preventing antigen escape with CAR T cell therapies are fully elucidated

CD19 antigen is not the only identified anti-tumor target for CAR T cell therapy.

Mechanisms of incomplete tumor elimination by CAR T cells are being further investigated

Question Title

* 4. Which statement about Natural Killer (NK) cell receptors is CORRECT?

NK cell receptors are encoded by genes that undergo somatic rearrangements

NK cell exclusively have activating receptors

All NK cell receptors are referred to as, “immunoglobulin-like receptors”

NK cell inhibitory receptors recognize major histocompatibility complex (MHC) class I molecules

Question Title

* 5. Which statement best describes the term “adult stem cell plasticity”

Ability of tissue-specific stem cells to acquire the fate of cell types different from the tissue of origin

Ability of stem cells to migrate from bone marrow niche to bloodstream

Reprogramming of activated hematopoietic stem cells to G_₀state

All of the above