PVD/ISTH/ATVB/AVF CROWD SOURCED SURVEY

1.What is your Organization?

American Venous Forum

International Society on Thrombosis and Haemostasis

American Heart Association - ATVB Council

American Heart Association - PVD Council

Other (please specify)

2.If you could award $50 million US dollars for basic thrombosis research, what would be the 5 most important topic(s) to study from the following list? You can propose your own favorite topic in the text box.

Interactions between inflammation, leukocytes, platelets, endothelium and the vessel wall in the initiation of thrombosis

Endothelial damage in the initiation of arterial and venous thrombosis

Trauma-induced coagulopathy

Hemostatic dysfunction after traumatic brain injury

Differences in hemostatic and thrombotic pathways among organs and vascular beds

Dependence of thrombus composition on location within the vasculature

Role of erythrocytes in thrombus development

Contribution of neutrophil extracellular traps (NETs) to thrombosis

Defining and exploiting mechanistic differences between thrombosis and hemostasis

Discovery and preclinical validation of novel antithrombotic targets

Influence of the gut microbiome on hemostasis and thrombosis

Mechanisms that determine the timing and location of venous thrombosis initiation

Distinguishing the mechanisms that cause venous thrombosis and pulmonary embolism

Platelet adhesion pathways in cardiovascular disease and thrombosis

Platelet signaling pathways in thrombus initiation and propagation

Pathways of cancer-associated thrombosis

Inherited and acquired alterations in hemostatic function

Modulators of the platelet transcriptome and consequences for hemostasis

LVAD-associated bleeding and thrombosis

Origin, composition and thrombotic properties of microvesicles

I would rather support research on

3.Please choose the 3 most important research topics in clinical arterial thrombosis.

Identifying better clinical strategies for pre-operative management of patients to reduce adverse cardiovascular outcomes (stroke, MI, CVD death) after vascular surgery

Defining best adjuvant medical therapy to maintain lower extremity bypass graft patency

Studying why smoking appears more atherogenic in the peripheral artery circulation as opposed to coronary artery circulation

Determining methods to separate the contribution of ischemic from non-ischemic causes of diabetic foot ulcer

Improving PAD Awareness among the public

Improving PAD Awareness among primary care physicians

Improving PAD Awareness among cardiovascular specialists

Developing intra-procedural techniques to identify culprit lesions (as we do with fractional flow reserve [FFR] and optical coherence tomography [OCT] in the coronary arteries)

Developing and testing protocols for clinical and imaging follow up of prior lower extremity interventions

Improving our understanding of the natural history of PAD and triggers for acute limb ischemia

Understanding the root causes of racial disparities in PAD incidence

Identifying mechanisms for peripheral stent and graft occlusion

Other (please specify)

4.Please choose the 3 most important research topics in clinical venous thrombosis.

Improving DVT diagnosis strategies

Improving PE diagnosis strategies

Improving post-thrombotic syndrome diagnosis strategies

Improving VTE awareness among the public

Improving the use of existing anticoagulants

Studying the role of existing anticoagulants for post-thrombotic syndrome prevention

Testing new anticoagulants for VTE treatment

Testing new invasive therapies for VTE treatment

Developing and testing new treatment pathways (including implementing current evidence into practice)

Identifying the age of a venous thrombus

Preventing VTE recurrence

Improve our understanding of the mechanisms of recurrent VTE

Other (please specify)