On behalf of the ASTCT Committee on Education, we are pleased to continue our monthly self-directed learning quiz "Basic Principles and Practices of Hematopoietic Cell Transplantation and Cell Therapy – Question and Answer Approach” for fellows in training, highlighting HCT and cell therapy topics. Answers to each question appear with evidence-based “non-exhaustive” peer-review commentary. Our aim is to provide you with a credible and freely available educational resource. Questions generated and reviewed by Syed Abutalib, MD, Amrita Krishnan, MD, and William A. Wood, MD.

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* 1. Which of the following statements about pathophysiology of cytokine release syndrome is CORRECT?

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* 2. Which of the following statements about clinical presentation and diagnosis of CRS is CORRECT?

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* 3. Which of the following statements about concepts of managing CRS is CORRECT?

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* 4. Which of the following statements about use of tocilizumab in CRS is CORRECT?

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* 5. Which of the following statements about use of corticosteroids in the management of CRS is CORRECT?

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