QBoost Question of the Month - July 2019

Question Title

* A 37-year-old patient was reviewing her previous IVF cycle outcome with her physician. She had been on a standard 300 IU daily gonadotropin agonist protocol for which only 3 follicles developed, and 1 oocyte was retrieved. She was told that she met the Bologna criteria for being a poor responder and was then counseled about the best protocol for her. She asked if she should follow a protocol her friend tried which increased the gonadotropin doses every several days over the previous dosage.

Which of the following statements about using a mild stimulation protocol for her are supported by the literature? (Choose two).

A. Randomized controlled trials exist to provide adequate direction about the use of mild ovarian stimulation protocol but live births as an outcome are not reported.

B. For outcomes measured in studies addressing this question, there was no difference between mild ovarian stimulation protocols and conventional gonadotropin protocols.

C. The literature supports increasing the dose of gonadotropins for the next cycle for this patient.

D. If she uses a mild ovarian stimulation protocol, she will likely use a lower total gonadotropin dosage, but the duration of medication will likely be longer.