Aspiration Pneumonia and Life-Threatening Bowel Obstruction: Unexpected Complications of Clozapine

Authors:

Steven W. Samuels, PharmD, BCPS
Transitions of Care Clinical Pharmacist| Whole Person Care
Los Angeles County Department of Health Services

Amy Liu, PharmD
Clinical Pharmacology and Therapeutics Postdoctoral Fellow
University of California, San Francisco

Richard Duong, PharmD, BCPP
Clinical Pharmacist
Los Angeles County Department of Health Services
 
Activity type: Knowledge-based
Audience: Pharmacists and pharmacy residents
 
Learning objectives:
After completion of the article, the reader will be able to:
1.     Describe the general pathophysiology of sialorrhea, gastrointestinal hypomotility, and their associated risks with clozapine or other antipsychotic medication use.
2.     Identify signs and symptoms of clozapine-induced sialorrhea and gastrointestinal hypomotility, and their specific complications of aspiration pneumonia and life-threatening bowel obstruction.
3.     List general pharmacologic and non-pharmacologic approaches for managing sialorrhea and gastrointestinal hypomotility in an adult patient.
Describe the general published evidence base for various pharmacologic treatments for clozapine-induced sialorrhea and gastrointestinal hypomotility.
 
ACPE – pharmacist accreditation credit hour: 0.75
 
The ACPE Universal Activity Number: 0217-9999-21-001-H01-P
For the successful completion, participants must pass a post-test with a score of 70% or higher.
 
CE Exam available at: https://www.surveymonkey.com/r/NCCCPClozapine
 
This is a free CE activity with no financial support from an individual or an organization.
 
The American College of Clinical Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.
 
The American College of Clinical Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. This activity is a knowledge-based activity and will provide 0.75 contact hour of continuing pharmacy education. To claim continuing pharmacy education credit participants must visit www.accp.com/ce and enter the code provided for exams scoring 70% or higher.  All participants must have a valid NABP e-Profile ID and date of birth on file with ACCP and must claim their CPE credit on the ACCP website by March 5, 2021.  Statements of credit for this activity will be available on CPE Monitor approximately 2-3 business days after credit has been claimed on the ACCP website.

Please be sure you have an account with ACCP before beginning this exam. If you are not a member of ACCP, a free account can be created at: https://www.accp.com/signin/register.aspx 

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* 2. What is your ACCP ID Number? If you are not a member of ACCP, a free account can be created at: https://www.accp.com/signin/register.aspx

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