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- Active exposure to oral stressors (smoke, alcohol) and/or low oral hygiene
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- Weight loss
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- Low nutritional profile and/or basal PCR value
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- Metabolic comorbidities (e.g. diabetes)
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- Genetic susceptibility (e.g. polymorphism in detoxifying enzymes)
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- Performance status
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- planned radiotherapy dose on superior pharyngeal constrinctor muscles
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- planned radiotherapy dose on mucosa of oral cavity and oropharynx
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- radiotherapy in postoperative setting
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- concurrent use of radiosensitizing chemotherapy
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