*1.Maria, a 22-year-old female patient, has eosinophilic/type 2 severe asthma. Maria’s lab results show WBC=5000/µL; EOS=250/µL; FeNO=50ppb; total IgE=80. All other labs are within normal range. Keeping in mind the importance of biomarkers for guiding treatment, which of the following would you most likely select for her?(Required.)

Add-on biologic therapy

LTRA

Tiotropium

Bronchial thermoplasty

*2.What class of biologic would you choose for Maria?(Required.)

Anti-IgE

Anti-IL-4R

Anti-IL-5/Anti-IL-5R

*3.Based on Maria’s non-allergic type 2 phenotype, she and her doctor agree on an initial trial of add-on biologic therapy. According to GINA recommendations, how long should you wait before evaluating her treatment response?(Required.)

2-4 months

4-5 months

6-12 months