October 2018 ASBMT Monthly Self-Directed Learning Quiz

On behalf of the ASBMT Committee on Education, we are pleased to continue our monthly self-directed learning quiz "Basic Principles and Practices of Hematopoietic Cell Transplantation and Cell Therapy – Question and Answer Approach” for fellows in training, highlighting HCT and cell therapy topics. Answers to each question appear with evidence-based “non-exhaustive” peer-review commentary. Our aim is to provide you with a credible and freely available educational resource. Questions generated and reviewed by Syed Abutalib, MD, Mark R. Litzow, MD, and William A. Wood, MD.

Question Title

* 1. Concerning the following pair of recipient and donor HLA typing, which is the true statement? (HLA mismatch indicated in bold)

Recipient

A∗02:01 B∗27:02 C∗02:02 DRβ1∗04:01 DQβ1∗03:02 DPβ1∗01:01
A∗25:01 B∗18:02 C∗12:03 DRβ1∗14:54 DQβ1∗05:03 DPβ1∗02:02

Donor

A∗02:01 B∗18:02 C∗02:02 DRβ1∗04:01 DQβ1∗03:02 DPβ1∗01:01
A∗25:01 B∗18:02 C∗12:03 DRβ1∗14:54 DQβ1∗05:03 DPβ1∗02:02

A. Recipient is more likely to have graft-versus-host disease

B. Recipient is more likely to have graft rejection

C. Both A and B are correct

Question Title

* 2. Which of the following options reflect correct order of gene expression sequence?

A. Translation→transcription→splicing

B. Transcription→splicing→translation

C. Transcription→translation→splicing

D. Splicing→transcription→translation

Question Title

* 3. Which statement about passenger lymphocyte syndrome is CORRECT?

A. It is characterized by severe lymphopenia

B. It is caused by engraftment of donor’s lymphocytes in the graft

C. It is a complication associated with major ABO mismatch allogeneic transplant

D. None of the above

Question Title

* 4. Which of the following statements about donor lymphocyte infusion is CORRECT?

A. There are randomized data which support its use in all patients with relapsed disease

B. It appears to be most beneficial for acute myeloid leukemia relapses

C. It can cause graft-versus-host disease

D. All of the above

Question Title

* 5. Which of the following statements about mortality from allogeneic transplantation is CORRECT?

A. Among HLA-matched sibling transplant recipients, within the first 100 days, primary disease accounts for the majority of deaths

B. Among unrelated donor allogeneic hematopoietic cell transplantation, within 100 days, mortality related to infection, organ failure, graft-versus-host disease accounts for the majority of deaths

C. Among HLA-matched sibling transplant recipients, at or after 100 days, infection and organ failure represent the majority of deaths.

D. Among unrelated donor allogeneic hematopoietic cell transplantation, after 100 days, mortality related to infection, organ failure, and graft-versus-host disease accounts for the majority of deaths.