On behalf of the ASTCT Committee on Education, we are pleased to continue our monthly self-directed learning quiz "Basic Principles and Practices of Hematopoietic Cell Transplantation and Cell Therapy – Question and Answer Approach” for fellows in training, highlighting HCT and cell therapy topics. Answers to each question appear with evidence-based “non-exhaustive” peer-review commentary. Our aim is to provide you with a credible and freely available educational resource. Questions generated and reviewed by Syed Abutalib, MD, Amrita Krishnan, MD, and William A. Wood, MD.

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* 1. Approximately 40 to 50% of all allogeneic hematopoietic cell transplantations are performed across the ABO blood-group barrier1-4.

Approximately, what proportion of transplants are minor ABO incompatible?

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* 2. Passenger lymphocyte syndrome is a well-described complication after minor ABO incompatible transplantation1-7.
 
Which statement about “passenger lymphocyte syndrome” is CORRECT?

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* 3. Minor ABO incompatible transplant (O→A, donor-recipient, respectively):  Which of the following platelet product is the preferred first choice for the recipient following the peritransplant phase of transplant?

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* 4. The adverse events associated with minor ABO incompatible transplantations are predicated by the existence or production of donor antibodies directed at ABO blood group antigens expressed on recipient red blood cells1-7.

Which of the following complication(s) may be observed after minor ABO incompatible transplantation?

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* 5. Which of the following donor-recipient blood group pairs is a major ABO incompatible hematopoietic allogeneic cell transplant?

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