HESI BIOACCUMULATION COMMITTEE SURVEY

Purpose of the survey

The purpose of this survey is to identify key areas of focus for the HESI Bioaccumulation Committee to evaluate and potentially address. This may lead to a re-focus of the goals and objectives of the group, given advances since the committee was formed in 2004.

Of particular interest are how bioaccumulation data (specifically) and toxicokinetic (TK) data (more broadly) are currently used in the ecological risk assessment context. TK describes and quantifies the processes and rates of chemical absorption, distribution, metabolism (biotransformation) and elimination (ADME) in an organism. These biokinetic processes play an important role in ecological (and human health) assessments by influencing a substance’s fate, exposure, bioaccumulation, and toxicity.

Moving beyond “B’ criteria, we are interested in exploring how both bioaccumulation and TK (ADME) data are currently used to inform chemical evaluations, whether they could be used more effectively, what scientific gaps need to be filled, and how the broader ecological assessment framework can be enhanced / modified.

Overall, the ultimate goal is to improve and strengthen the science that underpins effective ecological assessment in a fit-for-purpose, resource appropriate manner.

This survey will take you about 10 minutes, but you will be able to save your progress, and complete it at a later time.

Finally, note that your name and contact information will be used for internal purpose only, and will not be shared with anyone.

1.First Name

2.Last Name

3.Email address

4.Affiliation

6.Check the boxes what describe you(Required.)

I generate toxicokinetic (ADME) data

I use toxicokinetic (ADME) data

I generate bioaccumulation data

I use bioaccumulation data

Other (please specify)

None of the above

7.What kind of bioaccumulation or TK (ADME) data are you most interested in?

What taxa/species?

What type(s) of ADME data?

What chemistries?

In silico, in vitro, in vivo, field data? Others?

Any comment?

8.In what context do you use bioaccumulation and/or TK (ADME) data?

Other (please specify)

9.Based on your experience, how much are the different aspects of TOXICOKINETICS (ADME) outlined in the first row (In silico, in vitro approaches…etc.) used in practice to inform the areas listed in the first column. (Please, scroll to the right to see the entire table.)

In silico (Aquatic organisms)

In vitro (Aquatic organisms)

In vivo (Aquatic organisms)

Field (Aquatic organisms)

In silico (Terrestrial organisms)

In vitro (Terrestrial organisms)

In vivo (Terrestrial organisms)

Field (Terrestrial organisms)

PBT Classification

Screening

Prioritization

Ecological risk assessment

Human health risk assessment

Other (please specify)

10.For those categories that you ranked as “never used” and “sometimes used”, please indicate the potential reasons as listed below.

Aquatic data are not used because the science is not yet developed

Aquatic data are not used because there are no mechanisms / frameworks to use this information within the decision context

Aquatic data are not used because there are no regulatory / product safety requirement to do so

Aquatic data are not used because the data are not easily accessible / in a standardized format

Terrestrial data are not used because the science is not yet developed

Terrestrial data are not used because there are no mechanisms / frameworks to use this information within the decision context

Terrestrial data are not used because there are no regulatory / product safety requirement to do so

Terrestrial data are not used because the data are not easily accessible / in a standardized format

Other (please specify)

11.If you had TOXICOKINETIC (ADME) data how would you use it? (or if you currently use TK data, how do you use it?)

To refine food web models

To predict bioaccumulation

To evaluate chemical toxicity (e.g., explore the relationships between external and internal exposure doses.)

I don’t see a need for toxicokinetic data

Other (please specify)

12.What specific developments would be needed to realize the full potential of TOXICOKINETIC data?

Method development (e.g., in vitro assays)

Model development (e.g., IVIVE models, population models, etc.)

Data collection in additional species / taxa

Data collection in broader chemical space

Better access to existing data / models

Better connection across disciplines

Better translation / communication between regulators & scientists

Development of frameworks / approaches that facilitate the use of these data

Other (please specify)

13.Based on your experience, how much are the different aspects of BIOACCUMULATION science outlined in the first row (In silico, in vitro approaches…etc.) used in practice to inform the areas listed in the first column.

In silico (Aquatic organisms)

In vitro (Aquatic organisms)

In vivo (Aquatic organisms)

Field (Aquatic organisms)

In silico (Terrestrial organisms)

In vitro (Terrestrial organisms)

In vivo (Terrestrial organisms)

Field (Terrestrial organisms)

PBT Classification

Screening

Prioritization

Ecological risk assessment

Human health risk assessment

Other (please specify)

14.For those categories that you ranked as “never used” and “sometimes used”, please indicate the potential reasons as listed below.