February 2018 ASBMT Monthly Self-Directed Learning Quiz

On behalf of the ASBMT Committee on Education, we are pleased to continue our monthly self-directed learning quiz "Basic Principles and Practices of Hematopoietic Cell Transplantation and Cell Therapy – Question and Answer Approach” for fellows in training, highlighting HCT and cell therapy topics. Answers to each question appear with evidence-based “non-exhaustive” peer-review commentary. Our aim is to provide you with a credible and freely available educational resource. Questions generated and reviewed by Syed Abutalib, MD, Mark R. Litzow, MD, and William A. Wood, MD.

Question Title

1. Engineered therapeutic T cell therapies combine concepts from which of the following long-standing therapeutic strategies?

A) Engineered antibodies

B) Vaccination

C) Transplantation

D) All of the above are correct

E) Only A and B are correct

Question Title

2. What was the most common indication of hematopoietic cell transplantation in the U.S in the year 2014?

A) Lymphoma

B) Acute myeloid leukemia

C) Multiple myeloma/plasma cell disorders

D) Myelodysplastic syndromes

Question Title

3. Which statement about chronic graft-versus-host disease is correct?

A) Unlike acute graft-versus-host disease, chronic graft-versus-host disease does not affect hepatobiliary system

B) It remains one of the major causes of late transplant-related mortality

C) It does not affect pancreatic tissue

D) Manifestations of chronic graft-versus-host disease are always widespread

Question Title

4. Which statement about HLA- matched sibling transplants and hematopoietic graft type in in adults (age≥18 years) is correct?

A) The trend of using HLA-matched sibling bone marrow grafts has increased over the last 15 years in adult recipients

B) Peripheral blood remains the major graft source using HLA-matched sibling donors in adult recipients

C) Regardless of the graft type the transplant activity using HLA-matched sibling donors has increased since the year 2000

D) In 2015, use of peripheral blood grafts increased when compared to the activity of previous 3 years

Question Title

5. Which of the following are risk factors for chronic graft-versus-host-disease?

A. Prior episode of acute graft-versus-host disease

B. Transplantation of grafts from male donors in female recipients

C. Receipt of bone marrow grafts

D. All of the above

E. Choices B and C

Question Title

* 1. Engineered therapeutic T cell therapies combine concepts from which of the following long-standing therapeutic strategies?

Question Title

* 2. What was the most common indication of hematopoietic cell transplantation in the U.S in the year 2014?

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* 3. Which statement about chronic graft-versus-host disease is correct?

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* 4. Which statement about HLA- matched sibling transplants and hematopoietic graft type in in adults (age≥18 years) is correct?

Question Title

* 5. Which of the following are risk factors for chronic graft-versus-host-disease?

1. Engineered therapeutic T cell therapies combine concepts from which of the following long-standing therapeutic strategies?

2. What was the most common indication of hematopoietic cell transplantation in the U.S in the year 2014?

3. Which statement about chronic graft-versus-host disease is correct?

4. Which statement about HLA- matched sibling transplants and hematopoietic graft type in in adults (age≥18 years) is correct?

5. Which of the following are risk factors for chronic graft-versus-host-disease?