On behalf of the ASBMT Committee on Education, we are pleased to continue our monthly self-directed learning quiz "Basic Principles and Practices of Hematopoietic Cell Transplantation and Cell Therapy – Question and Answer Approach” for fellows in training, highlighting HCT and cell therapy topics. Answers to each question appear with evidence-based “non-exhaustive” peer-review commentary. Our aim is to provide you with a credible and freely available educational resource. Questions generated and reviewed by Syed Abutalib, MD, Mark R. Litzow, MD, and William A. Wood, MD.

* 1. Engineered therapeutic T cell therapies combine concepts from which of the following long-standing therapeutic strategies?

* 2. What was the most common indication of hematopoietic cell transplantation in the U.S in the year 2014?

* 3. Which statement about chronic graft-versus-host disease is correct?

* 4. Which statement about HLA- matched sibling transplants and hematopoietic graft type in in adults (age≥18 years) is correct?

* 5. Which of the following are risk factors for chronic graft-versus-host-disease?