February 2018 ASBMT Monthly Self-Directed Learning Quiz

On behalf of the ASBMT Committee on Education, we are pleased to continue our monthly self-directed learning quiz "Basic Principles and Practices of Hematopoietic Cell Transplantation and Cell Therapy – Question and Answer Approach” for fellows in training, highlighting HCT and cell therapy topics. Answers to each question appear with evidence-based “non-exhaustive” peer-review commentary. Our aim is to provide you with a credible and freely available educational resource. Questions generated and reviewed by Syed Abutalib, MD, Mark R. Litzow, MD, and William A. Wood, MD.

Question Title

* 1. Engineered therapeutic T cell therapies combine concepts from which of the following long-standing therapeutic strategies?

A) Engineered antibodies

B) Vaccination

C) Transplantation

D) All of the above are correct

E) Only A and B are correct

Question Title

* 2. What was the most common indication of hematopoietic cell transplantation in the U.S in the year 2014?

A) Lymphoma

B) Acute myeloid leukemia

C) Multiple myeloma/plasma cell disorders

D) Myelodysplastic syndromes

Question Title

* 3. Which statement about chronic graft-versus-host disease is correct?

A) Unlike acute graft-versus-host disease, chronic graft-versus-host disease does not affect hepatobiliary system

B) It remains one of the major causes of late transplant-related mortality

C) It does not affect pancreatic tissue

D) Manifestations of chronic graft-versus-host disease are always widespread

Question Title

* 4. Which statement about HLA- matched sibling transplants and hematopoietic graft type in in adults (age≥18 years) is correct?

A) The trend of using HLA-matched sibling bone marrow grafts has increased over the last 15 years in adult recipients

B) Peripheral blood remains the major graft source using HLA-matched sibling donors in adult recipients

C) Regardless of the graft type the transplant activity using HLA-matched sibling donors has increased since the year 2000

D) In 2015, use of peripheral blood grafts increased when compared to the activity of previous 3 years

Question Title

* 5. Which of the following are risk factors for chronic graft-versus-host-disease?

A. Prior episode of acute graft-versus-host disease

B. Transplantation of grafts from male donors in female recipients

C. Receipt of bone marrow grafts

D. All of the above

E. Choices B and C