Quiz - Sessions 6 and 7

Question Title

* 1. Which of the following statements concerning viral RNA synthesis is incorrect:

The RNA genome must be copied end to end

mRNAs must be produced that can be translated by the cell

RNA polymerases were first identified by labeling cells with radioactive precursors

A positive strand viral RNA must enter the cell together with an RNA polymerase

A viral RNA polymerase copies the viral RNA genome

Question Title

* 2. Consider a virus with a plus strand RNA genome 8 kb in length, which encodes 8 proteins. Which of the following is a known mechanism for producing all 8 proteins from this genome?

A single polyprotein is synthesized which is then processed by proteases to form 8 proteins

The RNA is cleaved into 8 fragments, each of which is translated into a different protein

Immediately upon entering the cells, the viral RNA polymerase that is carried into the cell within the virus particle, produces 8 subgenomic mRNAs from the plus strand RNA genome

There is no way to produce multiple proteins from a eukaryotic RNA

Question Title

* 3. Which situation best illustrates the finding that for some viruses, the nucleic acid does not leave the particle:

Cap-snatching during the production of influenza viral mRNAs

Polyadenylation by slippage of RNA polymerase at intergenic sequences on the template

Synthesis of reovirus mRNAs

VPg priming of polioviral RNA synthesis

Question Title

* 4. Which of the following is considered mature mRNA?

The primary transcript produced in the nucleus

The RNA produced by pol I

The RNA produced by pol III

The RNA on ribosomes

Question Title

* 5. Which of the following statements does not accurately depict viral transcription?

Regulation may be accomplished by host and/or viral proteins

Rb is an example of a viral encoded co-activator

Some viral regulators bind host proteins

Patterns of regulation include positive or negative autoregulatory loops and transcriptional cascades

Question Title

* 6. Which of the following statements does not accurately depict RNA export from the nucleus?

Export is usually accomplished by host proteins through the nuclear pore complex

A protein complex that marks mature RNAs for export is assembled during splicing

Unspliced transcripts are never exported from the nucleus

The retroviral CTE and Rev bind components of the nuclear export machinery