Penn Center for Cancer Care Innovation Seminar |
Charu Aggarwal, MD, MPH
Friday, October 8, 2021 | 11:00 AM - 12:00 PM ET
Virtual | Open to Penn Affiliates
Integration of Plasma-Based Next Generation Sequencing into Clinical Practice for Management of Patients with Non-Small Cell Lung Cancer
Actionable mutations are present in 30% of patients with metastatic non-squamous (mNSq) non-small cell lung cancer (NSCLC) where administration of targeted therapy is associated with an overall survival benefit. Guidelines now recommend broad genomic profiling for newly diagnosed mNSq NSCLC patients, however several studies suggest that this is not routinely performed. Penn has successfully implemented “reflex” tissue-based next-generation sequencing (NGS) for mNSq NSCLC at the Hospital of the University of Pennsylvania (HUP). In a recent study, Dr. Aggarwal and colleagues demonstrated that the addition of plasma NGS to tissue NGS testing nearly doubled the rate of detection for actionable mutations. Dr. Aggarwal will describe a new project which seeks to build on this work by fully integrating plasma-based NGS into clinical pathways at HUP and at community oncology practice sites across the University of Pennsylvania Health System. Since the majority of lung cancer patients are treated in the community, it is critical to develop systems that work at both academic as well as community cancer programs.
Actionable mutations are present in 30% of patients with metastatic non-squamous (mNSq) non-small cell lung cancer (NSCLC) where administration of targeted therapy is associated with an overall survival benefit. Guidelines now recommend broad genomic profiling for newly diagnosed mNSq NSCLC patients, however several studies suggest that this is not routinely performed. Penn has successfully implemented “reflex” tissue-based next-generation sequencing (NGS) for mNSq NSCLC at the Hospital of the University of Pennsylvania (HUP). In a recent study, Dr. Aggarwal and colleagues demonstrated that the addition of plasma NGS to tissue NGS testing nearly doubled the rate of detection for actionable mutations. Dr. Aggarwal will describe a new project which seeks to build on this work by fully integrating plasma-based NGS into clinical pathways at HUP and at community oncology practice sites across the University of Pennsylvania Health System. Since the majority of lung cancer patients are treated in the community, it is critical to develop systems that work at both academic as well as community cancer programs.
Please provide your name and Penn email address in order to register. You will receive a Zoom link prior to the event. Contact Kerry Coughlin (kerry.coughlin@pennmedicine.upenn.edu) with questions.