Equine Journal Club - November 2025

Read the Journal Article:

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Six articles will be presented each year with an accompanying quiz consisting of 5-10 questions. You must correctly answer 80% of questions to receive credit, and Diplomates may take each quiz up to three (3) times.
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Article quizzes will expire 12 months after original posting and will no longer be available for credit after that date.
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* 1. What is your first name?

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* 2. What is your last name?

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* 3. What is your email address?

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* 4. To maximize amikacin efficacy, what synovial maximum concentration (Cmax)-to-MIC ratio is aimed for?

5:1 to 20:1

8:1 to 10:1

8:1 to 12:1

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* 5. What were the two methods of amikacin administration via IVRLP in this study?

2g amikacin alone and 2g amikacin followed by 52 ml 0.9% NaCl

2g amikacin followed by 100 ml 0.9% NaCl and 2g amikacin followed by 10 ml 0.9% NaCl

2g amikacin followed by 52 mL 0.9% NaCl and 2g amikacin diluted to 60 mL with 0.9% NaCl

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* 6. ___ reached the target minimum synovial concentration (> or = 160 ug/ml) necessary to treat infections caused by organisms with an MIC of 16 ug/ml.

All horses, regardless of treatment group

No horses

Horses in treatment group A but not in treatment group B

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* 7. Given this and previous studies, it seems prudent to deliver the perfusate over __ when performing IVRLP to maximize peak synovial concentrations.

1 minute

10 minutes

5 minutes

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* 8. The mean Tmax for each group was not significantly different and suggests that maintaining the tourniquet for __ following completion of the IVRLP is appropriate, which aligns with other studies.

10 minutes

15 minutes

20 minutes