ASBMT Monthly Self-Directed Learning Quiz - December 2017

On behalf of the ASBMT Committee on Education we are pleased to introduce "Basic Principles and Practices of Hematopoietic Cell Transplantation and Cell Therapy – Question and Answer Approach,” a new feature highlighting a particular hematopoietic cell transplant and cell therapy quiz. Answers to each question appear with evidence-based “non-exhaustive” peer-review commentary. Our aim is to provide you with a credible and freely available educational resource. Questions generated and reviewed by Syed Abutalib, MD, Mark R. Litzow, MD, and William A. Wood, MD.

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* 1. Experiments and observations in which of the following animal species encouraged further trials of marrow grafting between human leukocyte antigen (HLA)-matched human siblings?

A. Mice

B. Dogs

C. Pigs

D. Rabbits

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* 2. All of the following statements about hematopoietic stem cells (HSCs) are correct EXCEPT:

A. HSCs are predominantly in G0 state in the marrow space

B. Contrary to other types of stem cells , HSCs have limited ability of self-renewal

C. HSCs can exit quiescence state and rapidly expand and differentiate

D. Activated hematopoietic stem cells can return to dormancy

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* 3. Which statement from the Guidelines of American Society for Blood and Marrow Transplantation (ASBMT) on indication for autologous and allogeneic hematopoietic cell transplant (HCT) is CORRECT?

A. The guidelines were developed in response to a need identified by patients, providers, payers and policy makers

B. Indications for HCT are categorized into three groups in the ASBMT guidelines

C. The goal is to update these guidelines every 12 to 18 months

D. These guidelines answer whether HCT should be pursued as a treatment for an individual patient

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* 4. All of the following statements about current uses of allogeneic hematopoietic cell transplantation (allo-HCT) by donor type in U.S. are true EXCEPT:

A. The number of unrelated donor (URD) transplants has surpassed the number of allo-HCT from related donors after the year 2006

B. The numbers of URD and HLA-identical siblings has shown a downward trend in absolute numbers after the year 2012

C. There has been an increase in the numbers of HLA-haploidentical transplants from the year 2012 onwards

D. There has been steady increase in the numbers of transplants using cord blood grafts from the years, 2003 to 2015

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* 5. Which statement about trends of autologous hematopoietic cell transplants (auto-HCT) in U.S. by recipient age is CORRECT?

A. The total number of auto-HCT for neoplastic diseases in older adults continues to decline

B. In the year 2015, 25% of the total auto-HCTs were performed in older adults with lymphomas and multiple myeloma

C. There is a trend towards increase use of auto-HCT in older (≥70 years of age ) adults

D. There is a trend towards decrease use of auto-HCT in multiple myeloma in patients’ ≥70 years of age