Shelter Medicine Journal Club - July 2026

Read the Journal Article:

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Six articles will be presented each year with an accompanying quiz consisting of 5-10 questions. You must correctly answer 80% of questions to receive credit, and Diplomates may take each quiz up to three (3) times.
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Article quizzes will expire 12 months after original posting and will no longer be available for credit after that date.
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Question Title

1. What is your first name? (Required.)

Question Title

2. What is your last name? (Required.)

Question Title

3. What is your email address? (Required.)

Question Title

4. Given that feline coronavirus prevalence in shelter environments approaches 100%, which of the following management strategies is most aligned with the internal mutation hypothesis presented by the authors? (Required.)

Routine molecular screening of all cats on intake to identify and isolate FCoV-positive animals

Reduction of housing density, stress levels, and intake flow rates to minimize conversion of low-pathogenicity FCoV to high-pathogenicity variants within individual cats

Prophylactic antiviral treatment with GS-441524 for all FCoV-positive cats to prevent FIP development

Question Title

5. The authors argue that what appears to be a “feline infectious peritonitis outbreak” in a shelter cluster of FIP cases most likely represents: (Required.)

Horizontal transmission of high-pathogenicity FCoV-1 from infected cats to naive animals

Recombination between FCoV-1 and FCoV-2 in the shelter population, generating a novel pathogenic strain

Multiple independent conversions of low-pathogenicity FCoV-1 to high-pathogenicity variants within individual cats exposed to a shared viral reservoir and stressors

Question Title

6. A shelter veterinarian receives a report of a positive feline coronavirus PCR test from a 3-month-old kitten on intake with mild diarrhea and no systemic signs. The most appropriate interpretation is: (Required.)

The kitten should be isolated immediately to prevent transmission to other animals and monitored for signs of FIP

The kitten is shedding FCoV and likely represents the 70-80% of infected cats that intermittently shed low levels of virus; a positive PCR result does not establish a FIP diagnosis

The kitten has latent FCoV infection and will require prophylactic antiviral therapy to prevent future FIP development

Question Title

7. FCoV-23 represents a departure from the typical epidemiologic pattern of FCoV-1 because it: (Required.)

Spreads horizontally between cats with high efficiency and is associated with a truncated spike protein domain, consistent with the authors’ description of the recent Cyprus outbreak

Is derived entirely from canine coronavirus without FCoV-1 genetic material and therefore poses risks to dogs as well as a zoonotic risk to humans

Causes only the “dry” form of FIP with exclusive respiratory tropism, distinguishing it from traditional FCoV that causes primarily gastrointestinal disease

Question Title

8. A shelter cat has recovered from FIP following successful antiviral therapy and is now available for adoption. Based on the authors' discussion of viral persistence, sanctuary compartments, and persistent uncertainty regarding viral reactivation after treatment, which of the following represents the most appropriate communication to the prospective adopter? (Required.)

"Your new cat has been successfully treated for FIP and is healthy. FIP is now curable with antiviral therapy, so your cat poses no documented disease risk and can be safely placed in a multi-cat household without special precautions."

"Your cat's FIP is in remission following antiviral treatment, and clinical signs have resolved. However, we cannot guarantee that the virus has been completely eliminated or that viral shedding has ceased. If you have other cats in your home, we recommend that you discuss the potential risks with your veterinarian and consider careful monitoring and management strategies."

"Your cat's FIP is in remission following antiviral treatment, and clinical signs have resolved. However, because treated cats may remain persistently infected with FCoV, this cat can only be safely adopted into a home without other dogs or cats. Please discuss a long-term monitoring and treatment plans with your veterinarian."

Shelter Medicine Journal Club - July 2026

Question Title

* 1. What is your first name? (Required.)

Question Title

* 2. What is your last name? (Required.)

Question Title

* 3. What is your email address? (Required.)

Question Title

* 4. Given that feline coronavirus prevalence in shelter environments approaches 100%, which of the following management strategies is most aligned with the internal mutation hypothesis presented by the authors? (Required.)

Question Title

* 5. The authors argue that what appears to be a “feline infectious peritonitis outbreak” in a shelter cluster of FIP cases most likely represents: (Required.)

Question Title

* 6. A shelter veterinarian receives a report of a positive feline coronavirus PCR test from a 3-month-old kitten on intake with mild diarrhea and no systemic signs. The most appropriate interpretation is: (Required.)

Question Title

* 7. FCoV-23 represents a departure from the typical epidemiologic pattern of FCoV-1 because it: (Required.)

Question Title

1. What is your first name? (Required.)

2. What is your last name? (Required.)

3. What is your email address? (Required.)

4. Given that feline coronavirus prevalence in shelter environments approaches 100%, which of the following management strategies is most aligned with the internal mutation hypothesis presented by the authors? (Required.)

5. The authors argue that what appears to be a “feline infectious peritonitis outbreak” in a shelter cluster of FIP cases most likely represents: (Required.)

6. A shelter veterinarian receives a report of a positive feline coronavirus PCR test from a 3-month-old kitten on intake with mild diarrhea and no systemic signs. The most appropriate interpretation is: (Required.)

7. FCoV-23 represents a departure from the typical epidemiologic pattern of FCoV-1 because it: (Required.)