International Survey on Tumor Regression Grading Systems for Gastrointestinal Carcinomas

This is an international survey being sent out to pathologists in multiple nations with special interest in GI. In this way, we hope to achieve a broad, world-wide view about the usage of tumor regression grading (TRG) for post-neoadjuvant treated gastrointestinal carcinomas (i.e. esophageal, gastric and rectal cancer) in daily practice and capture opinions regarding critical issues in grading. The results of this survey may help to work out a more standardized way to report on therapy induced changes in GI carcinomas. It should take less than 10 minutes to fill out. Your contribution is highly appreciated and we hope that the results of this study will provide valuable information about this topic.

Best regards,

Rupert Langer, MD, Associate Professor, University of Bern, Bern, Switzerland

Maria Westerhoff, MD, Associate Professor, University of Michigan, Ann Arbor, USA

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* 1. How many post-neoadjuvant therapy gastrointestinal resections do you sign out per year?

0 - 10/year

11 - 20/year

> 20/year

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* 2. Do you use a standardized protocol for the work up of resection specimens?

Yes

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* 3. How many blocks do you submit of the tumor bed in a post-neoadjuvant GI resection case?

up to 3 blocks

several blocks (>3)

complete, up to certain size of lesion (if huge I don't submit the whole thing)

always completely submitted

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* 4. Choose your histological work-up of the gastrointestinal resection specimen.

HE plus special stains

HE plus IHC

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* 5. If you submitted the entire lesion and you don't see residual cancer, do you order deeper sections?

no, never

yes, if blocks are not cut adequately

yes, always

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* 6. Are you using Tumor Regression Grading systems for gastrointestinal carcinomas?

Yes