Canine & Feline Journal Club - May 2025

Read the Journal Article:

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How to meet your Maintenance of Certification (MOC) quota:

Six articles will be presented each year with an accompanying quiz consisting of 5-10 questions. You must correctly answer 80% of questions to receive credit, and Diplomates may take each quiz up to three (3) times.
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Article quizzes will expire 12 months after original posting and will no longer be available for credit after that date.
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* 1. What is your first name?

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* 2. What is your last name?

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* 3. What is your email address?

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* 4. Which of the following statements is most true regarding metronidazole administration and the intestinal microbiome in this study?

The abundance of Clostridium perfringens was not significantly altered.

The Dysbiosis Index (DI) decreased, reflecting decreased species diversity and abundance of key organisms.

Organisms of the order Lactobacillales significantly decreased in abundance.

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* 5. The authors in this study demonstrated that the effects of metronidazole on the microbiome persist for as long as what period of time after its discontinuation?

4 days.

14 days.

28 days.

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* 6. Administration of metronidazole had which of the following effects on the intestinal microbiome at days 7 and 14 in this study?

Increased the Dysbiosis Index (DI).

Increased the abundance of Clostridiales.

Increased the abundance of Fusibacteria.

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* 7. Which was an observed side effect of metronidazole in healthy dogs?

Diarrhea, with some showing persistent dysbiosis and bile acid dysmetabolism.

An improved fecal score, bile acid metabolism, and overall digestion.

An enhanced microbiome diversity as demonstrated by a decreased Dysbiosis Index (DI).

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* 8. What is a key limitation of studying the effects of metronidazole in only healthy dogs?

The changes in the microbiome may not also reflect those in dogs with gastrointestinal disease.

Healthy dogs have a less diverse microbiome, making any changes more difficult to discern.

The effects of metronidazole on healthy dogs are always temporary and fully reversible.