Cardiac Amyloidosis – A Multidisciplinary Approach to Understanding, Diagnosis and Treatment

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* 1. The most common TTR mutation in African-Americans is:

V30M

V122I

T60A

L111M

V82I

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* 2. An adverse prognostic factor for survival in AL Amyloidosis patients is:

A λ/κ ratio of 10

Female gender

Left ventricular mass index > 125 g/m2

NT-proBNP ≥ 1800ng/L

Troponin-I ≥ 0.05 ng/mL

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* 3. Which of the following is the appropriate cardiac imaging test to order for the identification of ATTR (transthyretin) cardiac amyloidosis?

123I-MIBG (meta-iodobenzylguanidine)

18F-FDG (fluoro-deoxyglucose

Tc99m-PYP (pyrophosphate)

Tc99m-Sestamibi

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* 4. Which are the appropriate laboratory tests to order for the identification of AL (light-chain) cardiac amyloidosis?

Troponin I/T and nT-pro-BNP

Serum plasma electrophoresis (SPEP) and urine plasma electrophoresis (UPEP)

CBC with differential and serum calcium

Serum immunofixation electrophoresis (SIFE) and serum free light chains (FLC)

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* 5. Which of the following non-cardiac biopsies has the highest sensitivity for amyloid in patients with senile ATTR cardiac amyloidosis?

Abdominal fat pad fine needle aspiration.

Rectal biopsy.

Labial salivary gland biopsy.

Skin biopsy.

Non-cardiac biopsies cannot be used to identify ATTR amyloidosis.

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* 6. Which is true of cardiac biopsies for amyloidosis?

Severe biopsy-related complications are common.

Sensitivity and specificity are close to 100%.

They are necessary in all patients with cardiac amyloidosis.

They are required to determine the type of amyloid present.

They are never necessary since amyloid can always be identified in non-cardiac biopsies.

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* 7. Genotyping should be performed for:

Only TTR amyloid diagnosed at age 80 or less

All patients with cardiac amyloid: AL and TTR

TTR amyloid diagnosed by PYP scan without a positive tissue biopsy

Only TTR amyloid without mutation detected by mass spectometry tissue typing

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* 8. Which statements are true about AL amyloidosis and ASCT?

It has been demonstrated in a randomized controlled trial that ASCT is the best therapy for AL amyloidosis

There are really no good chemotherapy options other than ASCT for patients with AL amyloidosis

Both statements are true

Neither statement is true

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* 9. Which statements are true about chemotherapy for AL amyloidosis?

Chemotherapy targeting the bone marrow plasma cells reduces free light chains, which are the precursor protein for AL amyloid

At best, chemotherapy stabilizes the cardiomyopathy; no major clinical improvement is expected or possible

Both statements are true

Neither statement is true

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* 10. Which statements are true about drug therapies for ATTR amyloidosis?

The same chemotherapies used for AL amyloidosis can be used for ATTR amyloidosis

There are no FDA approved drugs with an indication to treat either AL or ATTR amyloidosis in the U.S.

Both statements are true

Neither statement is true

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* 11. Please provide your first and last name.
Pre-test questions will not be scored, your name is required solely to confirm completion.

First Name & Last Name

Question Title

* 1. The most common TTR mutation in African-Americans is:

Question Title

* 2. An adverse prognostic factor for survival in AL Amyloidosis patients is:

Question Title

* 3. Which of the following is the appropriate cardiac imaging test to order for the identification of ATTR (transthyretin) cardiac amyloidosis?

Question Title

* 4. Which are the appropriate laboratory tests to order for the identification of AL (light-chain) cardiac amyloidosis?

Question Title

* 5. Which of the following non-cardiac biopsies has the highest sensitivity for amyloid in patients with senile ATTR cardiac amyloidosis?

Question Title

* 6. Which is true of cardiac biopsies for amyloidosis?

Question Title

* 7. Genotyping should be performed for:

Question Title

* 8. Which statements are true about AL amyloidosis and ASCT?

Question Title

* 9. Which statements are true about chemotherapy for AL amyloidosis?

Question Title

* 10. Which statements are true about drug therapies for ATTR amyloidosis?

Question Title

* 11. Please provide your first and last name.Pre-test questions will not be scored, your name is required solely to confirm completion.

* 11. Please provide your first and last name.
Pre-test questions will not be scored, your name is required solely to confirm completion.