The following is evidence to support the origin of some ovarian cancers in the fallopian tube:
o Pathologic examination of tubes and ovaries from BRCA positive patients undergoing prophylactic BSO has shown that 10% of these patients will have a malignant or premalignant lesion at the time of surgery
o The majority of lesions found on BRCA+ patients undergoing prophylactic BSO are found in the fimbriated end of the fallopian tube rather than the ovary
o Fallopian tubes have been identified as the site of primary serous carcionoma in the general population (non-BRCA mutation carriers) as well
o Fallopian tube epithelial cells can transform into pathologically/immunophenotypically high-grade serous carcinoma.
Given the above information, please choose the answer that most accurately describes your level of comfort with the following…