ASBMT Monthly Self-Directed Learning Quiz - January 2018

On behalf of the ASBMT Committee on Education we are pleased to introduce "Basic Principles and Practices of Hematopoietic Cell Transplantation and Cell Therapy – Question and Answer Approach,” a new self-directed learning quiz highlighting hematopoietic cell transplant and cell therapy topics. Answers to each question appear with evidence-based “non-exhaustive” peer-review commentary. Our aim is to provide you with a credible and freely available educational resource. Questions generated and reviewed by Syed Abutalib, MD, Mark R. Litzow, MD, and William A. Wood, MD.

Question Title

* 1. Which statement about hematopoietic cell transplant comorbidity index (HCT-Cl) is INCORRECT?

A. It was designed using data from patients treated with allogeneic hematopoietic cell transplantation (allo-HCT)

B. It has been validated on numerous occasions

C. It is an important decision making instrument to select intensity of conditioning regimen for allo-HCT

D. It can be used alone to determine outcomes after allo-HCT.

Question Title

* 2. Which statement accurately defines the concept of linkage disequilibrium within the human leukocyte antigen (HLA) system?

A. Linkage disequilibrium implies that certain alleles occur together with a higher frequency than expected by chance.

B. Linkage disequilibrium is less frequently observed between loci that are in close proximity with a gene

C. Linkage disequilibrium implies that certain alleles do not occur together in a gene

D. Linkage disequilibrium is not observed between loci that are in close proximity

Question Title

* 3. Peripheral blood versus marrow graft sources in unrelated donor setting: All of the following statements are true according to the study published in New England Journal of Medicine by Anasetti and colleagues (2012) EXCEPT:

A. Peripheral-blood grafts may reduce the risk of graft failure

B. Marrow grafts may reduce the risk of chronic GvHD

C. Neutrophils engraftment was faster with marrow grafts

D. Overall survival at 2 years did not differ significantly between the peripheral blood and the marrow graft sources

Question Title

* 4. Which of the following is NOT a vital component of cryopreservation process for hematopoietic cell therapy product (CTP)?

A. Infusion of acid-citrate-dextrose (ACD) into CTP

B. Warming of CTP

C. Post-thaw cell assessment of CTP

D. Cooling protocol for CTP

Question Title

* 5. What is the leading cause of reported deaths after autologous hematopoietic cell transplant (auto-HCT) in the years 2013 and 2014?

A. Organ Failure

B. Infection

C. Primary disease

D. Second malignancy