May 2018 ASBMT Monthly Self-Directed Learning Quiz

On behalf of the ASBMT Committee on Education, we are pleased to continue our monthly self-directed learning quiz "Basic Principles and Practices of Hematopoietic Cell Transplantation and Cell Therapy – Question and Answer Approach” for fellows in training, highlighting HCT and cell therapy topics. Answers to each question appear with evidence-based “non-exhaustive” peer-review commentary. Our aim is to provide you with a credible and freely available educational resource. Questions generated and reviewed by Syed Abutalib, MD, Mark R. Litzow, MD, and William A. Wood, MD.

Question Title

* 1. Which of the following Dynamic International Prognostic Scoring System (DIPSS) or DIPSS plus risk categories is widely accepted indication for allogeneic hematopoietic cell transplantation for primary myelofibrosis?

A. Low-risk DIPSS

B. Intermediate-1 risk DIPSS plus

C. Intermediate-2 risk DIPSS or DIPSS plus

D. None of the above

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* 2. Which statement about chronic graft-versus-host disease (cGvHD) is correct?

A. The outcome with current therapies for cGvHD is unsatisfactory

B. The incidence of cGvHD has decreased

C. Approximately, 20% of allogeneic hematopoietic cell transplant recipients develop cGvHD

D. All of the above statements are true

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* 3. Which statement about ABO group types is correct?

A. ABO antigen inheritance is dependent on HLA inheritance

B. ABO antigens are expressed exclusively on red blood cells

C. Antibodies directed against the ABO antigens appear during the first year of life

D. Genes determining ABO groups are located on chromosome 6

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* 4. Which statement about refined Disease Risk Index (DRI) as developed by Armand and colleagues¹⁶ for allogeneic hematopoietic cell transplantation is correct?

A. It was developed following analysis of prospective data

B. It stratified patients into risk groups across all age groups

C. It stratified patients into 4 groups with very different overall survival

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* 5. Which statement about marrow microenvironment is correct?

A. Cellular composition of marrow niche is completely characterized

B. Activated hematopoietic stem cells function in hypoxic zones of the marrow

C. CXCL12 adventitial reticular cells are specialized mesenchymal stem cells

D. CXCL12 adventitial reticular cells are source of stromal derived factor-1

Question Title

* 1. Which of the following Dynamic International Prognostic Scoring System (DIPSS) or DIPSS plus risk categories is widely accepted indication for allogeneic hematopoietic cell transplantation for primary myelofibrosis?

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* 2. Which statement about chronic graft-versus-host disease (cGvHD) is correct?

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* 3. Which statement about ABO group types is correct?

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* 4. Which statement about refined Disease Risk Index (DRI) as developed by Armand and colleagues16 for allogeneic hematopoietic cell transplantation is correct?

Question Title

* 5. Which statement about marrow microenvironment is correct?

* 4. Which statement about refined Disease Risk Index (DRI) as developed by Armand and colleagues¹⁶ for allogeneic hematopoietic cell transplantation is correct?