Severe Asthma Livestream #3 - Pretest (ID: i770-9)

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* 1. Please rate your level of confidence in your ability for each of the following categories:

	Very confident	Confident	Neutral	Little confidence	No confidence
Diagnose severe asthma and identify biomarkers	Diagnose severe asthma and identify biomarkers Very confident	Diagnose severe asthma and identify biomarkers Confident	Diagnose severe asthma and identify biomarkers Neutral	Diagnose severe asthma and identify biomarkers Little confidence	Diagnose severe asthma and identify biomarkers No confidence
Develop personalized treatment plans for severe asthma	Develop personalized treatment plans for severe asthma Very confident	Develop personalized treatment plans for severe asthma Confident	Develop personalized treatment plans for severe asthma Neutral	Develop personalized treatment plans for severe asthma Little confidence	Develop personalized treatment plans for severe asthma No confidence
Manage severe asthma in clinical practice	Manage severe asthma in clinical practice Very confident	Manage severe asthma in clinical practice Confident	Manage severe asthma in clinical practice Neutral	Manage severe asthma in clinical practice Little confidence	Manage severe asthma in clinical practice No confidence

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* 2. What is your degree?

MD/DO

NP/PA

Pharmacist

Nurse

Other (please specify)

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* 3. What is your specialty?

Allergy

Pulmonology

Other Specialist

Internal Medicine

Family Practice

Pediatrics

Other (please specify)

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* 4. In addition to confirmation of diagnosis, medication adherence, and correct inhaler technique, which of the following does GINA recommend evaluating to distinguish between severe asthma and difficult-to-treat asthma?

Presence of blood eosinophils ≥150 cells/µL

Severity of previous exacerbations

Potential risk factors and comorbidities

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* 5. Identifying asthma phenotypes is an important component of care. For each of the following patients, which asthma phenotype is most appropriate?

	Eosinophilic phenotype	Allergen-driven phenotype	OCS-dependent phenotype
Nick is a 25-year-old male with severe asthma. His blood eosinophil levels are 250 cells/µL. He has a history of seasonal allergies but skin prick tests are negative and total IgE is within normal range.	Nick is a 25-year-old male with severe asthma. His blood eosinophil levels are 250 cells/µL. He has a history of seasonal allergies but skin prick tests are negative and total IgE is within normal range. Eosinophilic phenotype	Nick is a 25-year-old male with severe asthma. His blood eosinophil levels are 250 cells/µL. He has a history of seasonal allergies but skin prick tests are negative and total IgE is within normal range. Allergen-driven phenotype	Nick is a 25-year-old male with severe asthma. His blood eosinophil levels are 250 cells/µL. He has a history of seasonal allergies but skin prick tests are negative and total IgE is within normal range. OCS-dependent phenotype
Jane is a 42-year old female with severe asthma. Her blood eosinophil levels are 130 cells/µL. Her total serum IgE is 155 kUA/L. She has a history of perennial allergies managed with OTC medications. She has had 2 courses of OCS in the past year following exacerbation.	Jane is a 42-year old female with severe asthma. Her blood eosinophil levels are 130 cells/µL. Her total serum IgE is 155 kUA/L. She has a history of perennial allergies managed with OTC medications. She has had 2 courses of OCS in the past year following exacerbation. Eosinophilic phenotype	Jane is a 42-year old female with severe asthma. Her blood eosinophil levels are 130 cells/µL. Her total serum IgE is 155 kUA/L. She has a history of perennial allergies managed with OTC medications. She has had 2 courses of OCS in the past year following exacerbation. Allergen-driven phenotype	Jane is a 42-year old female with severe asthma. Her blood eosinophil levels are 130 cells/µL. Her total serum IgE is 155 kUA/L. She has a history of perennial allergies managed with OTC medications. She has had 2 courses of OCS in the past year following exacerbation. OCS-dependent phenotype

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* 6. Eosinophilic granulomatosis with polyangiitis is characterized by the presence of asthma, eosinophils >10% of total white blood count, and ANCA positivity, while hypereosinophilic syndrome is characterized by which of the following eosinophil levels?

>500 cells/µL for >6 months

>1000 cells/µL for >6 months

>1500 cells/µL for >6 months

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* 7. Approximately what percentage of chronic rhinosinusitis cases have nasal polyps present (ie, CRSwNP)?

10%

20%

30%

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* 8. There is no strong data to guide asthma management during co-infection with COVID-19, though the AAAAI recommends which of the following with regard to controller medications during COVID-19?

Controller medications should be continued

Controller medications should be discontinued

Controller medications should be stopped in favor of OCS

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* 9. For each of the following patients, select the appropriate biologic therapy based on the information provided.

	Anti-IgE	Anti-IL-4R	Anti-IL-5/IL-5R
Joe is a 19-year-old male with severe asthma. He has had an exacerbation in the past 6 months and is currently uncontrolled on high-dose ICS. He has sensitization on skin prick testing. Blood eosinophils are 140 cells/µL.	Joe is a 19-year-old male with severe asthma. He has had an exacerbation in the past 6 months and is currently uncontrolled on high-dose ICS. He has sensitization on skin prick testing. Blood eosinophils are 140 cells/µL. Anti-IgE	Joe is a 19-year-old male with severe asthma. He has had an exacerbation in the past 6 months and is currently uncontrolled on high-dose ICS. He has sensitization on skin prick testing. Blood eosinophils are 140 cells/µL. Anti-IL-4R	Joe is a 19-year-old male with severe asthma. He has had an exacerbation in the past 6 months and is currently uncontrolled on high-dose ICS. He has sensitization on skin prick testing. Blood eosinophils are 140 cells/µL. Anti-IL-5/IL-5R
Samantha is a 17-year-old female with severe asthma that is corticosteroid-dependent. Her blood eosinophils are 196 cells/µL.	Samantha is a 17-year-old female with severe asthma that is corticosteroid-dependent. Her blood eosinophils are 196 cells/µL. Anti-IgE	Samantha is a 17-year-old female with severe asthma that is corticosteroid-dependent. Her blood eosinophils are 196 cells/µL. Anti-IL-4R	Samantha is a 17-year-old female with severe asthma that is corticosteroid-dependent. Her blood eosinophils are 196 cells/µL. Anti-IL-5/IL-5R
Suzanne is a 27-year-old female with severe asthma. Her FeNO is 23 ppb. She has had 2 exacerbations in the past year and her blood eosinophils are 335 cells/µL.	Suzanne is a 27-year-old female with severe asthma. Her FeNO is 23 ppb. She has had 2 exacerbations in the past year and her blood eosinophils are 335 cells/µL. Anti-IgE	Suzanne is a 27-year-old female with severe asthma. Her FeNO is 23 ppb. She has had 2 exacerbations in the past year and her blood eosinophils are 335 cells/µL. Anti-IL-4R	Suzanne is a 27-year-old female with severe asthma. Her FeNO is 23 ppb. She has had 2 exacerbations in the past year and her blood eosinophils are 335 cells/µL. Anti-IL-5/IL-5R