On behalf of the ASBMT Committee on Education, we are pleased to continue our monthly self-directed learning quiz "Basic Principles and Practices of Hematopoietic Cell Transplantation and Cell Therapy – Question and Answer Approach” for fellows in training, highlighting HCT and cell therapy topics. Answers to each question appear with evidence-based “non-exhaustive” peer-review commentary. Our aim is to provide you with a credible and freely available educational resource. Questions generated and reviewed by Syed Abutalib, MD, Mark R. Litzow, MD, and William A. Wood, MD.

Question Title

* 1. Which statement about programmed death 1 (PD-1) pathway is correct?

Question Title

* 2. Which of the following is the most efficient antigen presenting cell (APC) for activation of naive CD4+ T cells in lymph nodes?

Question Title

* 3. Which one of the following statements about peptide binding to MHC molecules is CORRECT?

Question Title

* 4. Which of the following statements about survival after hematopoietic cell transplantation for chronic myeloid leukemia (CML) is CORRECT? (CIBMTR data)

Question Title

* 5. Which of the following statements about survival after allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia (CLL) is CORRECT? (CIBMTR data)

T