April 2018 ASBMT Monthly Self-Directed Learning Quiz

On behalf of the ASBMT Committee on Education, we are pleased to continue our monthly self-directed learning quiz "Basic Principles and Practices of Hematopoietic Cell Transplantation and Cell Therapy – Question and Answer Approach” for fellows in training, highlighting HCT and cell therapy topics. Answers to each question appear with evidence-based “non-exhaustive” peer-review commentary. Our aim is to provide you with a credible and freely available educational resource. Questions generated and reviewed by Syed Abutalib, MD, Mark R. Litzow, MD, and William A. Wood, MD.

Question Title

* 1. Which statement about hematopoietic cell transplants for acute myeloid leukemia is correct?

A. The disease status at the time of transplant and the donor type are the major predictors of post-transplant survival

B. Disease status at the time of transplant is the only predictor of post-transplant survival

C. In pediatric population, the disease status at the time of transplant is the only predictor of post-transplant survival

D. In adult population, donor type is the only predictor of post-transplant survival

Question Title

* 2. Which statement about hematopoietic progenitor cell collection by apheresis is correct?

A. The procedure is highly selective for procurement of CD34+ cells

B. The procedure involves collection of white blood cells from whole blood using centrifugation‐based techniques

C. The procedure is limited to two type of apheresis machines

D. All of the above

Question Title

* 3. Which statement related to the use of citrate as an anticoagulant in acid-citrate dextrose-solution A during hematopoietic progenitor cell collection by apheresis is correct?

A. It is exclusively metabolized by the liver

B. Mild hyperkalemia is a common occurrence

C. Severe citrate toxicity is not uncommon complication

D. Citrate toxicity is manageable in most cases

Question Title

* 4. Which of the following addresses the suitability of the donor/recipient?

A. Pregnancy test

B. Recent travel to South Africa

C. Anti-nuclear antibody test

D. Hepatitis panel

Question Title

* 5. According to the Foundation for the Accreditation of Cellular Therapy (FACT) and the Joint Accreditation Committee of ISCT-EBMT (JACIE) International Standards for Hematopoietic Cellular Therapy, which statement regarding pregnancy testing is correct?

A. Serum pregnancy testing is required for all female donors

B. A pregnancy test shall be performed for all female donors with childbearing potential within 7 days prior to starting the donor mobilization regimen

C. A pregnancy test shall be performed for all female donors with childbearing potential within 5 days prior to the initiation of the recipient’s preparative regimen

D. A pregnancy test shall be performed for all female donors within 10 days prior to the initiation of the recipient’s preparative regimen