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INCREASES IN HDL-CHOLESTEROL AND THE HDL/LDL CHOLESTEROL RATIO DURING PROLONGED ENDURANCE EXERCISE John Doe, firstname.lastname@example.org, graduate student, Department of Exercise Science & Health Promotion, College of Education, Mentor: Dr.Physiology
Purpose: The influence of prolonged, low-intensity exercise (45% VO2max) until exhaustion on plasma lipid concentrations, in particular high-density lipoprotein cholesterol (HDL-C), and the time sequence associated with changes in these blood constituents was investigated in 10 trained subjects. Methods: The exercise consisted of walking on a motor-driven treadmill until exhaustion. Blood samples were drawn before, at 30 and 60 minutes after the beginning of exercise, at each hour after that until exhaustion, immediately before exhaustion, and after a 30-minute recovery period. Fluids were given during the exercise session and values were corrected for plasma volume change. Results: At exhaustion the total cholesterol concentration was significantly elevated by 3% and rose during the recovery period. The HDL-C level was significantly elevated within two hours after the start of exercise and by exhaustion (about 4.5 hours of exercise) had risen to 52.5 ± 2.3mg.dL-1, which represented a 10.8% increase above the pre-exercise concentration (47.4 ± 1.8mg.dL-1). The HDL/LDL cholesterol ratio followed a pattern similar to that described for HDL-C. Plasma free fatty acids (FFA) also increased linearly during the exercise period, but were not significantly correlated with HDL- C during exercise ( r = 0.14). Conclusions: These results suggest that prolonged, low-intensity exercise can acutely improve the lipid profiles of humans. Supported by a Grant from Ross Laboratories