Molecular Mechanisms of Growth Factors in Neoplasia and Oncogenic Transformation: Phosphorylation, Ubiquitination and the Transcriptome
David R. Brown, MD
Pediatric Endocrinology and Genomics
Applied Biomedical Consultants
Staff Physician, Children’s Hospitals and Clinics of Minnesota
Minneapolis, Minnesota
September 2, 2009
The participant will be able to:
1.Understand the cell cycle and its regulation by phase specific cyclins and CDKs and the relationship of normal regulation to proliferation and dysregulation to neoplastic transformation
2.Review the role of tryrosine kinase receptors in the coordination and modulation of growth factor signaling
3.Review the concept of oncogenes and tumor suppressor genes in the regulation of the cell cycle and their relationship to growth factors
4.Understand the concept of ubiquitin mediated proteosome degradation as regulatory process and facilitation for growth factor expression
5.Introduce the concept of the transcriptome in genome-wide regulation of gene expression