| Raw material costs and quality | | | | |
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| Manufacturing efficiency | | | | |
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| Energy costs | | | | |
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| Increasing new product pipeline | | | | |
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| Expanding into new markets (geographical) | | | | |
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| Expanding into new markets (therapeutic) | | | | |
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| Reducing product prices | | | | |
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| Ensuring quality | | | | |
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| Ensuring compliance | | | | |
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| Capacity utilization and downtime elimination | | | | |
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| Reducing equipment and material costs | | | | |
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| Increased international competition | | | | |
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| Competition from generics | | | | |
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| Workforce training and skills shortages | | | | |
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