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Cardiac Genetics - class IV variants

1.What is your occupation?
2.In which hospital do you work?
3.Please estimate what number of cardiac genetics patients are seen by your service each year
4.Is NGS-based inherited cardiac gene testing performed in the laboratory in your Genetics Centre?
5.If you do not perform NGS in house for this purpose, to which laboratory do you send your tests?
6.Do you have a sub-specialty interest in cardiac genetics or are you contracted to provide dedicated hours to cardiac genetics?
7.Is there a consultant Clinical geneticist within your unit who is sub-specialised in cardiac genetics?
8.Do you routinely discuss test results with a clinical cardiology team in a multidisciplinary meeting?
9.Considering DNA sequence variants classified as outlined here below: 

Class 1 = Benign
Class 2 = Likely benign
Class 3 = Variant of unknown significance,
Class 4 = Likely pathogenic,
Class 5 = Pathogenic

please select a response to the following questions:
Yes
No
Only to AFFECTED individuals for segregation analysis
Do you offer cascade testing to family members of a proband in whom a class 5 variant is identified?
Do you offer cascade testing to family members of a proband in whom a class 4 variant is identified?
Do you offer cascade testing to family members of a proband in whom a class 3 variant is identified?
10.Considering pre-test counselling for cascade testing of CLASS 4 variants,
Yes
No
I don't know/not sure
Not applicable, we never offer cascade testing for class 4 variants
Do you explain that there may be a degree of uncertainty about the pathogenicity of a class 4 variant?
Do you mention the possibility of the pathogenicity classification changing as new evidence emerges in the future?
11.How often, in your opinion, should routine variant reclassification be performed? Please select one option
12.In an asymptomatic individual that has NORMAL predictive testing for a familial Class 4 variant, please answer the following:
Yes
No
n/a - I would leave this decision to their cardiologist
Are you totally reassuring that they have no risk of developing the familial phenotype?
If they have not seen a cardiologist, do you refer them for assessment?
If they have seen a cardiologist and have no clinical signs, do you recommend discharge from follow-up?
Do you discuss their result at MDT meeting prior to making these clinical decisions? 
13.Do you have any other concerns regarding the use of NGS for investigation of inherited cardiac pathology? If so, please list here below (optional)
14.Which of the following situtations should trigger variant reclassification? Please select all that apply