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* 1. Please list your first name, last name, and email:

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* 2. What is your specialty?

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* 3. How many patients with colorectal cancer do you treat each week?

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* 4. The DNA polymerase epsilon (POLE) protein coding gene is associated with DNA mismatch repair.

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* 5. What is the tumor mutation burden (TMB, in mutations/megabase) cutoff for which there is an FDA indication for pembrolizumab in progressive solid tumors?

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